Serif: Non-viral DNA delivery with Goldilocks durability

Serif is pioneering engineered DNA medicines designed to overcome two longstanding barriers to DNA as a therapeutic modality: innate immune detection and inefficient nuclear delivery. Clearing those hurdles could unlock a durability window between mRNA and gene therapy.

Advances in AI-driven sequence design and lipid nanoparticle delivery have made that possible. “We had wondered for a very long time what might be possible when DNA became an engineerable biotechnology for the first time,” Serif CEO and Flagship Pioneering origination partner Jacob (Jake) Rubens told BioCentury...